Approx. 340 miles, 6 hours.
Straightforward actually (hopefully), if long! M1, M6, leaving at Junction 43, then at roundabout take the 1st exit onto the A69 (signposted Carlisle), at traffic signals turn right into Thirlwell Gardens (see map below).
The club car park (cost was £1.50) can be found by taking the first right immediately after Brunton Park into Victoria Place and then turn first right onto St Aidans Road. Otherwise street parking.